The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt
Fig 5
Proof-of-concept simulations for stochastic evolution of Hes1.
The black timecourse indicates the outcome from the deterministic model; red lines indicate the results of ten separate stochastic runs, with mean given by the blue line. The addition of extrinsic noise to the Hes1 production term changes the outcome from a lower to a higher expression level of Hes1 in three out of the ten cases.