Unifying view of mechanical and functional hotspots across class A GPCRs
Fig 3
Functional profiling of key sites for GPCR’s mechanical and structural networks.
(a) The list of known GPCRs functional sites in Table 2 is used for the ROC curve profiling of the top mechanical sites in Table 2 (red) and of those that have the highest structural coordination (number of contacts) across the receptor ensemble (blue). For reference, the performance of a random classifier is shown by the dashed black line. Color-coded representations of the average bridging score and of the average coordination number are shown for rhodopsin (PDB ID: 1F88) in panels (b) and (c), respectively. The representation in panel (b) is the same as in Fig 2. The coordination number averaged over the six receptors shown in panel (c) ranges from 18.7 (blue) to 47.4 (red).