Optimality principles reveal a complex interplay of intermediate toxicity and kinetic efficiency in the regulation of prokaryotic metabolism
Fig 6
Comparisons of intermediate toxicity distributions before (left), at (middle) and after strongly regulated enzymes for (A) transcriptional regulation and (B) post-translational regulation.
Yellow color indicates toxicity distributions for strongly regulated enzymes, and white color the corresponding toxicity distributions for direct downstream intermediates of weakly regulated enzymes (lower values indicate higher toxicity).