Optimality principles reveal a complex interplay of intermediate toxicity and kinetic efficiency in the regulation of prokaryotic metabolism
Fig 3
Relationship between regulatory effort and intermediate toxicity for low (A,B) and high enzyme costs (C,D).
(A,C) The fraction of regulation is displayed in blue for each enzyme. (B,D) The intermediate toxicity is depicted in yellow (white) for the case of a strongly (weakly) regulated enzyme and the toxicity threshold of intermediates before and after (lower values indicate higher toxicity). All plots show the distribution of values as a combination of violin- and box-plots indicating median and 25–75% percentile.