Effects of FGFR2 kinase activation loop dynamics on catalytic activity
Fig 7
QM/MM studies of the FGFR2 kinase phosphotransfer reaction.
(A) Three structures along the phosphotransfer reaction, with their corresponding reaction coordinate values. These structures correspond roughly to a reactant, transition state, and product state. (B) Electrostatic potential-derived partial charges of the phosphate group, two Mg2+ ions, and Arg664 guanidinium protons facing the phosphate group, as a function of the reaction coordinate.