Multiscale mutation clustering algorithm identifies pan-cancer mutational clusters associated with pathway-level changes in gene expression
Fig 6
A) Violin plot of the response of mTOR inhibitor Temsirolimus (IC50s, y-axis) across cancer cell lines. The cell lines are grouped (x-axis) as wild-type PTEN (WT), depicted with gray markers and gray violin outline, cell lines with any non-synonymous mutation in PTEN (Any), depicted in black, and cell lines with a mutation in one of the hotspots, depicted in blue. Mutation clusters and any non-synonymous mutation features that are significantly associated with drug response (FDR<10%) are depicted in red. B) Violin plot of the response of a PI3Kb inhibitor for mutation clusters in PIK3CA.