Modelling Systemic Iron Regulation during Dietary Iron Overload and Acute Inflammation: Role of Hepcidin-Independent Mechanisms
Fig 7
Hepcidin-mediated control and dietary uptake saturation are critical parameters for serum iron homeostasis under dietary iron overload.
Simulation of steady state serum iron levels as a function of the dietary iron content for different model variants. For comparison, a linear increase of serum iron levels with increased dietary iron content is depicted.