Modelling Systemic Iron Regulation during Dietary Iron Overload and Acute Inflammation: Role of Hepcidin-Independent Mechanisms
Fig 6
Iron overload as a consequence of an iron enriched diet leads to the preferential iron accumulation in the liver, which is quantitatively reproduced by the model considering NTBI uptake and liver ferritin storage.
A-The measured distribution of iron between the organs is reproduced by the model fits for both normal and an iron enriched diet. The iron content of all compartments increases in mice maintained for 4 weeks on an iron rich diet, with most iron accumulating in the liver (arrows). B-Measured liver iron content under conditions of dietary iron overload and in HAMP-KO mice as well as best fit for the full model and models lacking NTBI uptake or liver ferritin storage, or both.