Using Chemical Reaction Kinetics to Predict Optimal Antibiotic Treatment Strategies
Fig 8
Time above MIC is insufficient predictor when sub-MIC concentrations are biologically active.
These graphs show results from the numerical simulations shown in Fig 7. Antibiotic efficacy is measured in fold reduction of total bacterial load during 24h normalized to a bacterial population growing in the absence of antibiotics. Blue = peak concentration < MIC, red = peak concentration > MIC. The lower panels in (A) and (B) show sub- and supra-MIC concentrations separately for clarity. (A) This graph shows the correlation between TC>MIC and antibiotic efficacy. (B) This graph shows the correlation between area under the curve and antibiotic efficacy.