Using Chemical Reaction Kinetics to Predict Optimal Antibiotic Treatment Strategies
Fig 6
Correlation between pharmacokinetic drivers and time until average cells are predicted to killed with isoniazid.
This graph shows the time until the threshold fc is reached after simulated bolus injections (model 2b) of 5-100x MIC isoniazid (typical Cmax values during therapy are at around 25x MIC [51, 52]) and a half-life of 0.5 – 4h. We used experimentally determined values for the MIC (0.1mg/l) for M. tuberculosis [53]. The different panels show the correlation between the time until the threshold is reached and different pharmacokinetic measures: (A) time above MIC; (B) area under the curve; (C) Cmax. We correlated the logarithm of tonset with the logarithm of the three pharmacokinetic indices in single linear regressions.