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Using Chemical Reaction Kinetics to Predict Optimal Antibiotic Treatment Strategies

Fig 4

Turnover rate and target occupancy at MIC determine end of antibiotic action.

This graph illustrates the time course of drug-target dissociation after 99.9% of the target was bound according to an exponential decay . Blue: t_bound = 11.5 min (k_r = 10⁻³), yellow: t_bound = 36.5 min (k_r = 10^−3.5), green: t_bound = 1h 55min (k_r = 10⁻⁴). The grey lines at 90%, 50% and 10% illustrate when the fraction of bound target falls below a particular threshold f_c.

doi: https://doi.org/10.1371/journal.pcbi.1005321.g004