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Real Time Multiplicative Memory Amplification Mediated by Whole-Cell Scaling of Synaptic Response in Key Neurons

Fig 8

In the balanced state, whole cell balanced amplification functions as a stable and robust linear amplifier.

A. For each level of intrinsic excitability (indicated by the color bar) the multiplication factor induced by whole-cell balanced amplification was calculated for different strengths of net synaptic input (, x-axis) using Eq 2. We examined the sensitivity of the multiplication factor to the net synaptic current by normalizing it to its mean value (Y -axis). For all intrinsic excitability levels (), indicated by the color bar), the value was close to one, indicating an almost constant multiplication factor. The image above the color bar helps to visualize , by indicating for each value of (and thus for the aligned color) the proportion of the voltage above the threshold when the mean synaptic current was zero. B. The mean multiplication factor (Y-axis) was calculated for each level of intrinsic excitability (, X-axis).

doi: https://doi.org/10.1371/journal.pcbi.1005306.g008