Real Time Multiplicative Memory Amplification Mediated by Whole-Cell Scaling of Synaptic Response in Key Neurons
Fig 7
Whole-cell balanced amplification increased the slope of the input-output curve through an increase of the average and the stdev of the membrane potential.
A. The number of spikes measured during an interval of 500 ms, before (yellow) and after (green) whole-cell balanced amplification is shown for increasing fractions of active strong synapses (red: 15%; orange: 30%; purple: 45% and blue: 60%) as evidenced by the increased net synaptic current (X-axis). Whole cell balanced amplification increased the gain of the spiking response to the same input. B. Slopes of the regression lines before (left) and after (right) whole-cell balanced amplification. In all simulations (20 different sets of simulations) the data matched a linear fit (r>0.95) C. Membrane potential before (left) and after (right) the amplification mechanism was applied.D. Distribution of the membrane potential before and after the amplification mechanism was applied. Whole-cell balanced amplification increased both the average and the standard deviation of the membrane potential. Black lines indicates the fit to a normal distribution where the amplification shifted the average by 3.7 mV and multiplied the stdev by 1.6.