Real Time Multiplicative Memory Amplification Mediated by Whole-Cell Scaling of Synaptic Response in Key Neurons
Fig 3
The cells in the CaMKII blocker affected cluster were affected by the task learning through whole-cell twofold multiplication of the GABAA single-channel current.
A. The average single channel current of the cells in the CaMKII affected cluster from the trained group (T-reduced) was approximately twice that of the average single channel current in the naïve group and the non affected trained group (T–not reduced). B. The amplitude distribution curve of the cells in the affected cluster in the trained group could be reconstructed by multiplying all events in the naive group by a factor of two (T-reduced, n = 9; T-not reduced, n = 12; naïve, n = 12). C. The trained group deviated from the control group mainly by the presence of the sub-group of cells that exhibited a large single channel current. D. The cumulative frequency distribution of the trained group could be explained by multiplying by two the average event amplitude of a randomly selected 35% of the cells in the naïve group (P<0.34 Kolmogorov-Smirnov test). Each point represents the average event amplitude in a neuron (x-axis).