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A General Shear-Dependent Model for Thrombus Formation

Fig 6

Simulation results for platelet aggregation at high shear rates with occlusion levels of 20–60% corresponding to the undisturbed maximum wall shear rates 2,000 − 6,000 s⁻¹.

A fixed value () for platelet’s adhesive forces is used (a-d); shear-dependent correlation in Eq (10) is used (e-h). (a), (b) and (c) Snapshots of platelet aggregation inside 60, 40 and 20% stenoses, respectively. (e), (f) and (g) Snapshots of platelet aggregation inside 60, 40 and 20% stenoses, respectively. No aggregation is found for 20% stenosis; (d) and (h) density of adhered platelets inside the stenosis vs. simulation time. Color coding for particles is the same as in Fig 3. Here, the activation delay time is τ_act = 0s.

doi: https://doi.org/10.1371/journal.pcbi.1005291.g006