A General Shear-Dependent Model for Thrombus Formation
Fig 4
Low-shear simulation results of blood clotting in a 50μm circular tube.
(a) A typical example of the number of platelets aggregated in the thrombus vs. time, plotted in semi-log axes. Exponential growth is achieved after a few seconds. The exponential growth rate is computed by fitting the data (red line). (b) Exponential growth rates (normalized by the maximum value) computed from the simulations and plotted as a function of blood flow velocity (−□−). Here, the size of injury is 30μm and platelet concentration is taken as 300,000mm−3; experimental data extracted from Begent and Born [19] (○). (c) Exponential growth rates derived from simulations for three different conditions: platelet concentration taken as 500,000mm−3 (−△−); increased size of injury to 60μm (−▽−); and the inclusion of shear-induced platelet’s drift according to Eq (6) (−○−). Results from (b) replotted here for comparison (−□−).