Transcriptional and Post-Transcriptional Regulation of Thrombospondin-1 Expression: A Computational Model
Fig 2
Reaction diagram of TSP-1 regulation by hypoxia and TGFβ signaling.
(A) HIF stabilization in hypoxia, induction of let-7 and regulation of TSP-1 mRNA by miR-18a. Transcription of TSP-1 gene is modulated by different factors. (B) TGFβ signaling and calcium-mediated activation of NFATc1. Species whose names end with an N subscript are located inside the nucleus; reactions that point to red signs indicate degradation. The symbols v# in the two subparts (A and B) refer to the chemical reactions listed in S1 Table.