Feedback Loops of the Mammalian Circadian Clock Constitute Repressilator
Fig 3
Cry1, Per2 and Rev-erb-α oscillations are most critical for circadian rhythm generation.
All possible combinations of gene-subsets were analyzed for oscillating solutions by clamping the remaining genes to their respective oscillation mean values (A: one gene clamped; B: three genes clamped). Blue bars indicate the percentage of parameter sets around the default values that result in oscillating solutions. Red bars depict the median period among these solutions. Only 3 of 10 combinations of 2 genes oscillate at all, which are shown in (B). Error bars give the upper and lower quartiles for the period.