Hierarchical Post-transcriptional Regulation of Colicin E2 Expression in Escherichia coli
Fig 4
Fluctuations in long mRNA abundance.
The fluctuations are quantified by the Fano factor (see main text) and depicted as heatmap in the plot. They are most pronounced at the threshold, and fade for parameter sets above the threshold. With an increase in sRNA production (NαS), the fluctuations become smaller and more localized to the threshold. This illustrates how the third component sRNA acts as a means to reduce intrinsic fluctuations. The production rate of CsrA dimers was again set to αA = 58.52, and all other system parameters are given in S1 Table.