Hierarchical Post-transcriptional Regulation of Colicin E2 Expression in Escherichia coli
Fig 2
Simplified interaction scheme for post-transcriptional regulation of long mRNA.
M,A,S: molecule numbers of free long mRNA, free CsrA dimers and the free effective sRNA; α: production rates; δ: degradation rates; k: effective rate of coupled degradation. The interaction network (see S1 Fig) of the regulatory system depicted in Fig 1 was reduced to a three component system. In both figures, the corresponding components have the same colors. In particular, we combined the complex dynamics (binding, dissociation, degradation) into an effective coupled degradation. The dynamics of sRNA complexes with N binding sites for CsrA and production rate αS were simplified to the dynamics of an effective sRNA with one CsrA binding site but N-times higher production rate (S1 Text).