The Limitations of Model-Based Experimental Design and Parameter Estimation in Sloppy Systems
Fig 3
Experimental design in sloppy system.
Sloppy models are characterized by an exponential distribution of FIM eigenvalues (left). Black lines are FIM eigenvalues for the model in question. Red lines represent additional eigenvalues that would be introduced by using a more realistic model. Optimal experimental design selects experiments so as to shift all the black eigenvalues above some desired threshold (dashed line). Under these new experimental conditions, the red eigenvalues could (1) remain irrelevant, (2) become relevant, or (3) become marginally relevant.