Modeling Cellular Noise Underlying Heterogeneous Cell Responses in the Epidermal Growth Factor Signaling Pathway
Fig 6
Effects of protein variability of each species on heterogeneity in nuclear ERK.
CV of nuclear ERK with changes in protein variability of each species at (A) low (0.05 ng/mL) and (B) high (50 ng/mL) concentrations of EGF. Circle size represents CV of nuclear ERK. (C) CV of nuclear ERK at various concentrations of EGF when changing protein variability of each species. The patterns of CV were classified into three types. CV of 25% was used as protein variability of each species. The gray region represents the area from EC10 (0.02 ng/mL) to EC90 (0.12 ng/mL) calculated from Fig 1D.