Modeling Cellular Noise Underlying Heterogeneous Cell Responses in the Epidermal Growth Factor Signaling Pathway
Fig 5
Effects of covariation among initial proteins on heterogeneity in ERK.
(A) An example of the relationship among proteins under initial conditions with and without covariation. Points represent different simulation data. (B) The distributions of steady-state levels of nuclear ERK at 25% CV of initial proteins under conditions of no stimulation with and without covariation. (C) CV of peak levels of nuclear ERK with and without covariation with or without application of AME.