Modeling Cellular Noise Underlying Heterogeneous Cell Responses in the Epidermal Growth Factor Signaling Pathway
Fig 2
Validation of EGF signaling pathway model.
The time courses of changes in (A) phosphorylated and (B) nuclear ERK levels at different concentrations of EGF (0–50 ng/mL) are shown. EGF dose response of peak levels at (C) phosphorylated and (D) nuclear ERK were calculated from deterministic simulations. Points and lines represent observed data [14] and simulation results, respectively. The effects of ERK-mediated regulation of NPC on the dose response of (E) phosphorylated and (F) nuclear ERK are shown. The Hill coefficients were obtained by curve fitting of simulation results.