Kinase Inhibition Leads to Hormesis in a Dual Phosphorylation-Dephosphorylation Cycle
Fig 4
Relationship between the maximum hormetic response and the flux C · kin · inh → C + inh · kin.
The maximum hormetic response is calculated as the maximal increase in CPP over all inhibitor doses, relative to the base line amount of CPP in the absence of inhibition. Since the baseline is represented at a level of 100%, hormesis is present if the maximum response strictly exceeds the baseline (> 100%). The flux is computed as e2[C · kin · inh] − e−2[C][kin · inh] using the steady state values [C](inh*), [kin · inh](inh*), [C · kin · inh](inh*) with inh* being the dose with the maximum hormetic response (see Fig 1). As e−2 increases, the flux decreases to 0.