Kinase Inhibition Leads to Hormesis in a Dual Phosphorylation-Dephosphorylation Cycle
Fig 3
The maximum hormetic response is calculated as the maximal increase in CPP over all inhibitor doses, relative to the base line amount of CPP in the absence of inhibition. Since the baseline is represented at a level of 100%, hormesis is present if the maximum response strictly exceeds the baseline (> 100%). This maximum response is plotted (black dots) as a function of different substrate-kinase ratios achieved by varying the total mass of substrate and keeping the total mass of kinase constant.