A Biophysical Systems Approach to Identifying the Pathways of Acute and Chronic Doxorubicin Mitochondrial Cardiotoxicity
Fig 7
A schematic of the mitochondrial model used.
The expressions of ATP synthase and Complexes I, III and IV of the ETC are scaled by the mtDNA content as these structures are encoded at mtDNA. The acute effects of DOX are highlighted in red.