WORMHOLE: Novel Least Diverged Ortholog Prediction through Machine Learning
Fig 6
WORMHOLE identifies LDO pairs with a similar distribution of BLASTp alignment quality and evolutionary distance to the PANTHER LDOs and excludes low-scoring PANTHER LDOs.
Box and whisker plots representing BLASTp Bit Score (A) or evolutionary distance (B) for alignments between longest protein isoforms for genes in each gene pair in the indicated ortholog dataset. Novel WORMHOLE LDOs are gene pairs predicted by WORMHOLE that are not present in the PANTHER LDO training set. Excluded PANTHER LDOs are gene pairs in the PANTHER LDO training set that are excluded by WORMHOLE.