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Topology, Cross-Frequency, and Same-Frequency Band Interactions Shape the Generation of Phase-Amplitude Coupling in a Neural Mass Model of a Cortical Column

Fig 8

Exploring the parameter space for three different PAC combinations.

A) Average cTE values for delta-gamma (orange), theta-gamma (green), and alpha-gamma (blue) PAC when considered 100 different values for nine different parameters: 1) a multiplying factor η = 0.03:0.03:3 controlling the global strength of the connectivity matrix (Γnm = ηΓnm), 2) the reciprocal of the time constant of RS populations (kRS = 5:5:500s−1), 3) the reciprocal of the time constant of IB populations (kIB = 5:5:500s−1), 4) the reciprocal of the time constant of LTS populations (kLTS = 5:5:500s−1), 5) the reciprocal of the time constant of FS populations (kFS = 5:5:500s−1), 6) the external input to the L4RS population (), 7) the external input to the L4FS population (), 8) the gains of the six excitatory populations (GEG1 = G2 = G5 = G8 = G9 = G12 = 0.2:0.2:20mV), and 9) the gains of the eight inhibitory populations (GIG3 = G4 = G6 = G7 = G10 = G11 = G13 = G14 = 0.5:0.5:50mV). B) Plot of cTE versus η. C) Average cTE values for direct and indirect PAC connections. Labels ‘d’, and ‘i’ correspond to direct and indirect PAC connections.

Fig 8

doi: https://doi.org/10.1371/journal.pcbi.1005180.g008