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Fundamental Activity Constraints Lead to Specific Interpretations of the Connectome

Fig 3

Bistability of the model.

A Sketch of the microcircuit model serving as a prototype for the areas of the multi-area model (figure and legend adapted from figure 1 of Potjans and Diesmann [23], with permission). B Sketch of the most common laminar patterns of cortico-cortical connectivity of the multi-area model. C Population-averaged firing rates encoded in color for a spiking network simulation of the multi-area model with low external drive . D As C but for increased external drive . The color bar refers to both panels. Areas are ordered according to their architectural type along the horizontal axis from V1 (type 8) to TH (type 2) and populations are stacked along the vertical axis. The two missing populations 4E and 4I of area TH are marked in black and firing rates in gray. E Histogram of population-averaged firing rates shown in C for excitatory (blue) and inhibitory (red) populations. The horizontal axis is split into linear- (left) and log-scaled (right) ranges. F as E corresponding to state shown in D.

doi: https://doi.org/10.1371/journal.pcbi.1005179.g003