Dynamic Cholesterol-Conditioned Dimerization of the G Protein Coupled Chemokine Receptor Type 4
Fig 4
Cholesterol occupation hotspots on CXCR4.
Cholesterol binding occupancy in simulations of CXCR4 dimerization at 10% cholesterol concentration. The color and thickness coded residue-resolved occupancy scale ranges from 0 to 65% time occupancy (red, thick). The inset shows a detailed view on the main cholesterol binding site at the TM1,7 interface with the main involved residues in stick representation. Additionally, a bound cholesterol molecule is depicted (gray).