Dynamic Cholesterol-Conditioned Dimerization of the G Protein Coupled Chemokine Receptor Type 4
Fig 3
TM1/TM5-7 and TM1/TM1 dimer interfaces and structure alignments.
Structure alignments between spontaneously formed TM1/TM5-7 dimer (a) as well as TM1/TM1 dimer (b), obtained from a 3 μs simulation in pure POPC and backmapped to atomistic resolution (colored TM helices), and the crystal structures of TM1/TM5-7 and TM1/TM1 found in PDB-entries 3OE8 and 3OE9, respectively (light grey). The interacting residues are highlighted as sticks and labeled.