Genetic Redundancies Enhance Information Transfer in Noisy Regulatory Circuits
Fig 7
Model of information transfer in gene regulatory circuits.
Intrinsic noise, genetic redundancy, and heterogeneity increase the transmission of information by expanding the capacity of the (summing) global output to represent the input variability. In contrast, extrinsic noise and cross-talk among redundant units become limiting factors by correlating the individual outputs of the units. Threshold genetic units represented here as gray circles; input signal x and output response y characterized by P(x) and P(y) distributions, respectively.