Large-Scale Off-Target Identification Using Fast and Accurate Dual Regularized One-Class Collaborative Filtering and Its Application to Drug Repurposing
Fig 8
(A) The drug clusters created based on the profile similarity with the anti-cancer drug cluster in the middle (darker blue grid). (B) The clusters of FDA-approved anti-cancer drugs. A set of 25 known anti-cancer drugs (blue boxes), and another set of 7 FDA-approved drugs that are closely linked to the former set but have not yet been approved for anti-cancer treatment (darker blue boxes). Procedures explained in the drug-target interaction profile analysis for drug repurposing section.