Mechano-chemical Interactions in Cardiac Sarcomere Contraction: A Computational Modeling Study
Fig 6
Tension and the proportion of activated troponin complexes (Tn) P(x) in the thin filament along the single overlap region.
A sarcomere with length 2.05 μm was modeled with constant calcium concentrations ([Ca]). The blue, purple, and magenta lines represent a [Ca] of 3, 4, and 5 μM, respectively. (A) The plot shows the non-linear cumulative tension developed at position x along the single overlap region. (B) P(x) is displayed. The plateaus reached at [Ca]’s of 4 and 5 μM represent the full activation of Tn’s, i.e. all binding sites on that section of the thin filament are exposed for XB binding.