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Mechano-chemical Interactions in Cardiac Sarcomere Contraction: A Computational Modeling Study

Fig 3

Build-up of tension in the thin filament.

Each cross-bridge (XB) generates an individual force FXB. Tension S(x) at location x is the sum of each individual XB force from the start of the single overlap region closest to the mid line (x = 0) to the position x. So, tension along the thin filament increases with each XB exerting force.

Fig 3

doi: https://doi.org/10.1371/journal.pcbi.1005126.g003