A Novel Drug-Mouse Phenotypic Similarity Method Detects Molecular Determinants of Drug Effects
Fig 5
a) Network of high scoring associations around the PROKR2 gene. PROKR2 is linked to the anabolic steroids oxandrolone and oxymetholone. The androgen receptor (AR) exhibits a high phenotypic similarity to known direct (blue) and indirect (green) targets of AR. The coloured hexagons indicate the pharmacological subgroup of the ATC classification system. b) Dose response curve of oxandrolone on the PKR2 antagonistic assay. Two replicate measurements, their average and the fitted dose-response curve are shown.