A Novel Drug-Mouse Phenotypic Similarity Method Detects Molecular Determinants of Drug Effects
Fig 3
Detection of protein-side effect relationships by the phenotypic similarity approach.
a) Network of shared associations between leptin and the leptin receptor and examples of utilized adverse effects (coloured dots). The coloured hexagons indicate the pharmacological subgroup of the ATC classification system. b) Boxplot of the fraction of causal protein-side effect links of low vs high scoring associations utilized in the scoring scheme. The *** denote that this fraction is significantly (P-value = 5.88E-10, Wilkoxon ranksum test) larger in the gene-drug pairs having a high similarity compared to the low scoring ones.