SUMOFLUX: A Generalized Method for Targeted 13C Metabolic Flux Ratio Analysis
Fig 3
SUMOFLUX is robust in terms of experimental noise and exchange flux magnitude.
(a) Mean absolute errors on the testing dataset of five flux ratio predictors applied to in silico data with different amount of measurement noise and exchange flux magnitude. The dashed rectangle indicates the normal range of noise (0.01) and exchange flux magnitude (10 times the net flux). (b) Mean absolute errors on the testing datasets with different noise levels of five flux ratio predictors trained on datasets with different amount of measurement noise. The exchange flux magnitude was set to 1 for all datasets. (c) Mean absolute errors on the testing dataset with different exchange flux magnitudes of five flux ratio predictors trained on datasets with different values of exchange flux magnitude. The noise level was set to 0.01 for all datasets. E-D—Entner-Doudoroff pathway, MAE—mean absolute error; PPP—pentose phosphate pathway.