A Computational Model of Hepatic Energy Metabolism: Understanding Zonated Damage and Steatosis in NAFLD
Fig 6
The simulated effects of varying dietary intake in the model.
(a-d) The average hepatic lipid content across the sinusoid when simulating varying glucose and FFA intake diets in individuals with (a) MH insulin sensitivity (100%, KIR = 1), (b) developing IR (5%, KIR = 0.05), (c) severe IR (1.5%, KIR = 0.015) and (d) severe IR in combination with increased SREBP-1c expression. (e-f) The effects of high fat and carbohydrate (glucose) intake on (e) ATP concentrations and (f) FFA concentrations across the sinusoid when simulating a MH, insulin sensitive individual. High and low intakes correspond to a sustained 12.5% difference in intake relative to the moderate intake det. Very high and raised intakes correspond to 25% and 5% increases respectively. The average concentrations over a 4 hours intake/output cycle are depicted.