A Computational Model of Hepatic Energy Metabolism: Understanding Zonated Damage and Steatosis in NAFLD
Fig 4
Metabolite concentrations when simulating NAFLD.
(a) The average triglyceride (b) FFA, (c) ATP, (d) glycerol-3-phosphate and (e) glycogen concentration and (f) the difference between postprandial peak and pre-prandial trough glycogen concentrations in the different regions of the sinusoid when simulating (purple) a MH individual, (orange) IR alone and (red) IR with increase SREBP-1c expression using a moderate intake diet.