Uncertainty-Dependent Extinction of Fear Memory in an Amygdala-mPFC Neural Circuit Model
Fig 3
Fear memory in the extended model when the vmPFC was activated and silenced.
(A) Schedules of CS and US; the presentation schedules for the CS and US during fear conditioning and extinction were the same as those used in the basic model (Fig 2A), but the resting phase, during which neither the CS nor the US was presented, and the retrieval phase, during which only the CS was presented to evaluate extinction memory, were set after extinction. (B-F) Extended model simulation results for the control condition (B), vmPFC activation during extinction (C), vmPFC activation during retrieval (D), vmPFC silencing during extinction (E) and vmPFC silencing during retrieval (F). The blue, green, red and black lines indicate the activity of the LA (persistent neurons), vmPFC (extinction neurons), ITC (another group of extinction neurons) and CEA (fear neurons), respectively. Note that overlapping lines were changed to dashed lines to make them visible.