Noncommutative Biology: Sequential Regulation of Complex Networks
Fig 5
The sequestration network is a noncommutative model of gene regulation by chromosome folding.
(A) A sequence of moves K3 K4 K1 P3 P4 on a hypothetical chromosome with K and P actions represented as DNA-binding factors and K1 playing the role of RNAP. Red circles correspond to genes and numbers correspond to allowed binding partners. (B) The same sequence in A represented as a collection of targets with up to n = 4 arms. For example, the target {0, 1, 2} corresponds to the gene locus with states 1 and 2 in A. The filled circle represents the current state.