Qualitative Dynamical Modelling Can Formally Explain Mesoderm Specification and Predict Novel Developmental Phenotypes
Fig 6
In situ RNA staining for two sets of single and double mutants.
A: Slp lof and Med lof each results in a perturbation of H. The double mutant displays an even stronger disruption of H, along with a clear expansion of Srp expression. These experimental results are largely consistent with our model predictions and further provide interpretational clues regarding mixed expression patterns. B: Slp gof exhibits a loss of VM, while FB appears perturbed in both Doc gof and Slp gof mutants. The combination of these perturbations leads to stronger losses of FB and VM, while H and SM are barely affected. These results qualitatively agree with model predictions.