Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells
Fig 8
The process diagram of the EPO-induced JAK2/STAT5 signaling pathway model is shown according to Systems Biology Graphical Notation. Identified parameter fold-changes between CFU-E and H838 cells are shown in red (higher in CFU-E: JAK2actEPO, EPORactJAK2, CISHRNAturn) or purple (higher in H838: STAT5imp, nSTAT5deact, SOCS3prom, SOCS3RNAdelay). Parameters with a more effective inhibition in H838 cells are shown in light blue (JAK2actEPO, EPORactJAK2, STAT5actJAK2, STAT5actEPOR, STAT5imp, STAT5exp, SOCS3RNAturn). The area-under-curve of npSTAT5 at 60 min after stimulation was used as read-out to calculate the sensitivities.