Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells
Fig 4
Generalized mathematical model structure of the EPO-induced JAK2/STAT5 signaling pathway.
The process diagram of the EPO-induced JAK2/STAT5 signaling pathway model is shown according to Systems Biology Graphical Notation. The binding of the ligand EPO to its cognate receptor results in the phosphorylation of first JAK2 and then of the EPOR (pEPORpJAK2). STAT5 is recruited by pEPOR and phosphorylated by pJAK2 and translocates to the nucleus where it induces the transcription of the negative feedback regulators CISH mRNA and SOCS3 mRNA. Protein tyrosine phosphatase (PTP) regulates the dephosphorylation of the EPOR-JAK2 complex.