Symbiotic Cell Differentiation and Cooperative Growth in Multicellular Aggregates
Fig 6
The stability of collective growth.
(A) Network 1 in the r2cell model for (C, V, D) = (0.1, 1, 0.1), representing unstable collective growth. (B) Network 2 in the r2cell model for (C, V, D) = (0.15, 3, 1), representing balanced collective growth. In (A) and (B), the horizontal axis denotes the volume ratio of the two cells, r(1)≡v(1)/(v(1) + v(2)), and each black line displays the growth rate in the r1cell model μ(iso). Blue circles and orange triangles denote the growth rate of type-1 μ(1) and type-2 μ(2), respectively. Green rectangles indicate the total growth rate of the cell aggregate μ(tot)≡r(1)μ(1) + r(2)μ(2). (C) and (D) show the cell number distribution in the N-cell model (N = 100). Blue, red, and gray bars designate the numbers of type-1, type-2, and non-differentiated cells, respectively. (C) Case for network 1 with (C, Vmed, D) = (0.01, 100, 0.1). (D) Case for network 2 with (C, Vmed, D) = (0.3, 50, 0.1).