Strain Mediated Adaptation Is Key for Myosin Mechanochemistry: Discovering General Rules for Motor Activity
Fig 5
Powerstroke of the myosin motors.
(A) Powerstroke step with the release of Pi. The residues involved in the Pi mediated interactions in terms of p-loop (blue), switch I (red) and switch II (green) are shown. (B) RMSD (with respect to pre-powerstroke crystal structure) distribution for the simulation with Pi mediated interaction. The population of the pre-powerstroke ensemble is higher. (C) RMSD (with respect to pre-powerstroke crystal structure) distribution for the simulation without Pi mediated interactions. Note the inversion of the distribution with phosphate release making post-powerstroke ensemble as the dominant one.