Strain Mediated Adaptation Is Key for Myosin Mechanochemistry: Discovering General Rules for Motor Activity
Fig 4
Strain regulates the ADP release kinetics of the trailing head.
(A) A schematic representation of myosin dimer showing how Pi release can create strain on the trailing head. This strain arises due to the postponed-powerstroke waiting state of the leading head (left head). (B) Probability distribution of distances between small and big subunits of the MH domain at different level of strain on the trailing head. This distribution shifts towards the larger distances as strain increases, which leads to an increase in ADP release rate with increasing strain.