Strain Mediated Adaptation Is Key for Myosin Mechanochemistry: Discovering General Rules for Motor Activity
Fig 2
Two important conformational states of the mechanical cycle of myosin.
(A) Pre- (PDB 2V26 [34]) and post-powerstroke (PDB 2BHK [36]) states of the myosin motor showing the motor head (MH) and the converter domains. Note the change in the conformation of the converter domain with respect to the MH in the two conformations. The competing interactions (contacts) between the MH and the converter domains, responsible for stabilizing these two states, are shown by lines. (B) Residue-residue contact map for both the conformations. The two dotted green lines are drawn to separate the contact maps of the MH and the converter domains. In the upper triangle, the post-powerstroke contact map (red) is overlaid upon the pre-powerstroke contact map (blue) to identify the exclusive converter-MH contacts in the pre-powerstroke state (shown by lines in Fig 2A). In contrast, the same data have been overlaid in opposite order (blue upon red) in the lower triangle to extract the exclusive converter-MH contacts in the post-powerstroke state (those interactions are shown by lines in Fig 2A).